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1

A Landscape of Driver Mutations in Melanoma

Eran Hodis, Ian R. Watson, Gregory V. Kryukov, Stefan T. Arold, Marcin Imielinski, Jean-Philippe Theurillat, Elizabeth Nickerson, Daniel Auclair, Liren Li, Chelsea Place, Daniel DiCara, Alex H. Ramos,

Journal:

Year:

2012

Language:

english

File:

PDF, 2.25 MB

english, 2012

2

Noise in cellular signaling pathways: causes and effects

John E. Ladbury, Stefan T. Arold

Journal:

Trends in Biochemical Sciences

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

3

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

Stefan T Arold, Andreas S Baur

Journal:

Trends in Biochemical Sciences

Year:

2001

Language:

english

File:

PDF, 201 KB

english, 2001

4

Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

Kadaré, Gress, Gervasi, Nicolas, Brami-Cherrier, Karen, Blockus, Heike, El Messari, Said, Arold, Stefan T., Girault, Jean-Antoine

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.22 MB

english, 2015

5

Mutations of PTPN23 in developmental and epileptic encephalopathy

Sowada, Nadine, Hashem, Mais Omar, Yilmaz, Rüstem, Hamad, Muddathir, Kakar, Naseebullah, Thiele, Holger, Arold, Stefan T., Bode, Harald, Alkuraya, Fowzan S., Borck, Guntram

Journal:

Year:

2017

Language:

english

File:

PDF, 964 KB

english, 2017

6

A Novel TBX1 Variant Causing Hypoparathyroidism and Deafness

Alghamdi, Malak, Al Khalifah, Reem, Al Homyani, Doua K, Alkhamis, Waleed H, Arold, Stefan T, Ekhzaimy, Aishah, El-Wetidy, Mohammed, Kashour, Tarek, Halwani, Rabih

Journal:

Journal of the Endocrine Society

Year:

2020

File:

PDF, 688 KB

2020

7

Shape-Induced Selective Separation of Ortho-substituted Benzene Isomers Enabled by Cucurbit[7]uril Host Macrocycles

Zhang, Gengwu, Emwas, Abdul-Hamid, Shahul Hameed, Umar F., Arold, Stefan T., Yang, Peng, Chen, Aiping, Xiang, Jun-Feng, Khashab, Niveen M.

Journal:

Year:

2020

File:

PDF, 2.92 MB

2020

8

Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2

Alam, Intikhab, Kamau, Allan A., Kulmanov, Maxat, Jaremko, Åukasz, Arold, Stefan T., Pain, Arnab, Gojobori, Takashi, Duarte, Carlos M.

Journal:

Frontiers in Cellular and Infection Microbiology

Year:

2020

File:

PDF, 1.15 MB

2020

9

Searching for specificity in SH domains

John E Ladbury, Stefan Arold

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

10

A Mutant Impaired in SNARE Complex Dissociation Identifies the Plasma Membrane as First Target of Synaptobrevin 2

Sonia Martinez-Arca, Stefan Arold, Rachel Rudge, Fabrice Laroche, Thierry Galli

Journal:

Year:

2004

Language:

english

File:

PDF, 4.43 MB

english, 2004

11

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

Rayne, Fabienne, Debaisieux, Solène, Yezid, Hocine, Lin, Yea-Lih, Mettling, Clément, Konate, Karidia, Chazal, Nathalie, Arold, Stefan T, Pugnière, Martine, Sanchez, Françoise

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

12

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check

Tonthat, Nam Ky, Arold, Stefan T, Pickering, Brian F, Van Dyke, Michael W, Liang, Shoudan, Lu, Yue, Beuria, Tushar K, Margolin, William, Schumacher, Maria A

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 1.78 MB

english, 2010

13

The H-NS dimerization domain defines a new fold contributing to DNA recognition

Bloch, Vanessa, Yang, Yinshan, Margeat, Emmanuel, Chavanieu, Alain, Augé, Marie Thérèse, Robert, Bruno, Arold, Stefan, Rimsky, Sylvie, Kochoyan, Michel

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 730 KB

english, 2003

14

Characterization and molecular basis of the oligomeric structure of HIV-1 Nef protein

Stefan Arold, François Hoh, Stephanie Domergue, Catherine Birck, Marc-André Delsuc, Magali Jullien, Christian Dumas

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 1.33 MB

english, 2000

15

A specific protein disorder catalyzer of HIV-1 Nef

Adrien Lugari, Sebastian Breuer, Thibault Coursindel, Sandrine Opi, Audrey Restouin, Xiaoli Shi, Alexis Nazabal, Bruce E. Torbett, Jean Martinez, Yves Collette, Isabelle Parrot, Stefan T. Arold, Xavie

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 596 KB

english, 2011

16

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin

Robert Schmalzigaug, Marie-Line Garron, J. Tyler Roseman, Yanghui Xing, Collin E. Davidson, Stefan T. Arold, Richard T. Premont

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 1.42 MB

english, 2007

17

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Xiaoli Shi, Stephane Betzi, Adrien Lugari, Sandrine Opi, Audrey Restouin, Isabelle Parrot, Jean Martinez, Pascale Zimmermann, Patrick Lecine, Mingdong Huang, Stefan T. Arold, Yves Collette, Xavier Mor

Journal:

Year:

2012

Language:

english

File:

PDF, 848 KB

english, 2012

18

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

Journal:

Current Opinion in Structural Biology

Year:

2011

Language:

english

File:

PDF, 809 KB

english, 2011

19

Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain

Maria K. Hoellerer, Martin E.M. Noble, Gilles Labesse, Iain D. Campbell, Jörn M. Werner, Stefan T. Arold

Journal:

Year:

2003

Language:

english

File:

PDF, 682 KB

english, 2003

20

ROP2 from Toxoplasma gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity

Gilles Labesse, Muriel Gelin, Yannick Bessin, Maryse Lebrun, Julien Papoin, Rachel Cerdan, Stefan T. Arold, Jean-François Dubremetz

Journal:

Year:

2009

Language:

english

File:

PDF, 1.43 MB

english, 2009

21

The Structural Basis of Localization and Signaling by the Focal Adhesion Targeting Domain

Stefan T Arold, Maria K Hoellerer, Martin E.M Noble

Journal:

Year:

2002

Language:

english

File:

PDF, 357 KB

english, 2002

22

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

Stefan Arold, Peet Franken, Marie-Paule Strub, Francois Hoh, Serge Benichou, Richard Benarous, Christian Dumas

Journal:

Year:

1997

Language:

english

File:

PDF, 793 KB

english, 1997

23

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

Chi-Chuan Lin, Fernando A. Melo, Ragini Ghosh, Kin M. Suen, Loren J. Stagg, John Kirkpatrick, Stefan T. Arold, Zamal Ahmed, John E. Ladbury

Journal:

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

24

Crystal Structure of the N-terminal Dimerisation Domain of VicH, the H-NS-like Protein of Vibrio cholerae

Rachel Cerdan, Vanessa Bloch, Yinshan Yang, Philippe Bertin, Christian Dumas, Sylvie Rimsky, Michel Kochoyan, Stefan T. Arold

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 932 KB

english, 2003

25

The Solution Structure of the Adhesion Protein Bd37 from Babesia divergens Reveals Structural Homology with Eukaryotic Proteins Involved in Membrane Trafficking

Stéphane Delbecq, Daniel Auguin, Yin-Shan Yang, Frank Löhr, Stefan Arold, Theo Schetters, Eric Précigout, André Gorenflot, Christian Roumestand

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 2.18 MB

english, 2008

26

Structural Basis for the Interaction between Focal Adhesion Kinase and CD4

Marie-Line Garron, James Arthos, Jean-François Guichou, Jonathan McNally, Claudia Cicala, Stefan T. Arold

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.17 MB

english, 2008

27

Structural Insights into the Association between BCAR3 and Cas Family Members, an Atypical Complex Implicated in Anti-Oestrogen Resistance

Marie-Line Garron, Diana Arsenieva, Jessie Zhong, Alexander B. Bloom, Adam Lerner, Geraldine M. O’Neill, Stefan T. Arold

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 2.45 MB

english, 2009

28

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli

Suen, Kin Man, Lin, Chi-Chuan, George, Roger, Melo, Fernando A, Biggs, Eleanor R, Ahmed, Zamal, Drake, Melanie N, Arur, Swathi, Arold, Stefan T, Ladbury, John E

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

29

Catalytic Protein Modification with Dirhodium Metallopeptides: Specificity in Designed and Natural Systems

Chen, Zhen, Vohidov, Farrukh, Coughlin, Jane M., Stagg, Loren J., Arold, Stefan T., Ladbury, John E., Ball, Zachary T.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 2.26 MB

english, 2012

30

SPIE Proceedings [SPIE SPIE Optical Metrology 2013 - Munich, Germany (Monday 13 May 2013)] Videometrics, Range Imaging, and Applications XII; and Automated Visual Inspection - Improved EEG source localization employing 3D sensing by "Flying Triangulation"

Ettl, Svenja, Remondino, Fabio, Shortis, Mark R., Rampp, Stefan, Fouladi-Movahed, Sarah, Beyerer, Jürgen, Puente León, Fernando, Dalal, Sarang S., Willomitzer, Florian, Arold, Oliver, Stefan, Hermann,

Year:

2013

Language:

english

File:

PDF, 813 KB

english, 2013

31

Phosphatidylinositol 4,5-Bisphosphate-Induced Conformational Change of Ezrin and Formation of Ezrin Oligomers

Carvalho, Kevin, Khalifat, Nada, Maniti, Ofelia, Nicolas, Claire, Arold, Stefan, Picart, Catherine, Ramos, Laurence

Journal:

Year:

2010

Language:

english

File:

PDF, 3.29 MB

english, 2010

32

RT Loop Flexibility Enhances the Specificity of Src Family SH3 Domains for HIV-1 Nef †,‡

Arold, Stefan, O'Brien, Ronan, Franken, Peet, Strub, Marie-Paule, Hoh, Francois, Dumas, Christian, Ladbury, John E.

Journal:

Year:

1998

Language:

english

File:

PDF, 146 KB

english, 1998

33

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer

Boulbes, Delphine R., Arold, Stefan T., Chauhan, Gaurav B., Blachno, Korina V., Deng, Nanfu, Chang, Wei-Chao, Jin, Quanri, Huang, Tzu-Hsuan, Hsu, Jung-Mao, Brady, Samuel W., Bartholomeusz, Chandra, La

Journal:

Molecular Oncology

Year:

2015

Language:

english

File:

PDF, 2.27 MB

english, 2015

34

How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine–aspartic acid (LD) motifs

Alam, Tanvir, Alazmi, Meshari, Gao, Xin, Arold, Stefan T.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

35

ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii

El Hajj, Hiba, Lebrun, Maryse, Arold, Stefan T., Vial, Henri, Labesse, Gilles, Dubremetz, Jean François

Journal:

Year:

2007

Language:

english

File:

PDF, 722 KB

english, 2007

36

How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions

Walkiewicz, Katarzyna W., Girault, Jean-Antoine, Arold, Stefan T.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.76 MB

english, 2015

37

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs

Naveed, Hammad, Hameed, Umar S., Harrus, Deborah, Bourguet, William, Arold, Stefan T., Gao, Xin

Journal:

Year:

2015

Language:

english

File:

PDF, 435 KB

english, 2015

38

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

Ritho, Joan, Arold, Stefan T., Yeh, Edward T.H.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.61 MB

english, 2015

39

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

Perlman, Elizabeth J., Gadd, Samantha, Arold, Stefan T., Radhakrishnan, Anand, Gerhard, Daniela S., Jennings, Lawrence, Huff, Vicki, Guidry Auvil, Jaime M., Davidsen, Tanja M., Dome, Jeffrey S., Meerz

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

40

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

Lissanu Deribe, Yonathan, Shi, Yanxia, Rai, Kunal, Nezi, Luigi, Amin, Samir B., Wu, Chia-Chin, Akdemir, Kadir C., Mahdavi, Mozhdeh, Peng, Qian, Chang, Qing Edward, Hornigold, Kirsti, Arold, Stefan T.,

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 2.01 MB

english, 2016

41

Beyond initiation-limited translational bursting: the effects of burst size distributions on the stability of gene expression

Kuwahara, Hiroyuki, Arold, Stefan T., Gao, Xin

Journal:

Integrative Biology

Year:

2015

Language:

english

File:

PDF, 3.09 MB

english, 2015

42

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation

Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

Journal:

Year:

2016

Language:

english

File:

PDF, 3.48 MB

english, 2016

43

H-NS forms a superhelical protein scaffold for DNA condensation

Stefan T. Arold, Paul G. Leonard, Gary N. Parkinson, John E. Ladbury and Brian W. Matthews

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

44

Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans

Alfadhel, Majid, Nashabat, Marwan, Qahtani, Hanan Al, Alfares, Ahmed, Mutairi, Fuad Al, Shaalan, Hesham Al, Douglas, Ganka V., Wierenga, Klaas, Juusola, Jane, Alrifai, Muhammad Talal, Arold, Stefan T.

Journal:

Year:

2016

Language:

english

File:

PDF, 718 KB

english, 2016

45

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

Shi, Xiaoli, Opi, Sandrine, Lugari, Adrien, Restouin, Audrey, Coursindel, Thibault, Parrot, Isabelle, Perez, Javier, Madore, Eric, Zimmermann, Pascale, Corbeil, Jacques, Huang, Mingdong, Arold, Stefan

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 956 KB

english, 2010

46

Pre-mRNA splicing repression triggers abiotic stress signaling in plants

Ling, Yu, Alshareef, Sahar, Butt, Haroon, Lozano-Juste, Jorge, Li, Lixin, Galal, Aya A., Moustafa, Ahmed, Momin, Afaque Ahmad, Tashkandi, Manal, Richardson, Dale N., Fujii, Hiroaki, Arold, Stefan, Rod

Journal:

The Plant Journal

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

47

KDF1, encoding keratinocyte differentiation factor 1, is mutated in a multigenerational family with ectodermal dysplasia

Shamseldin, Hanan E., Khalifa, Ola, Binamer, Yousef M., Almutawa, Abdulmonem, Arold, Stefan T., Zaidan, Hamad, Alkuraya, Fowzan S.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

48

Mechanistic basis for site-specific functions of focal adhesion kinase

Arold, Stefan T., Brami-Cherrier, Karen, Gervasi, Nicolas, Walkiewicz, Katarzyna W., Kadareé, Gress, Girault, Jean-Antoine

Journal:

Acta Crystallographica Section A Foundations and Advances

Year:

2015

File:

PDF, 600 KB

2015

49

In silico screening for candidate chassis strains of free fatty acid-producing cyanobacteria

Motwalli, Olaa, Essack, Magbubah, Jankovic, Boris R., Ji, Boyang, Liu, Xinyao, Ansari, Hifzur Rahman, Hoehndorf, Robert, Gao, Xin, Arold, Stefan T., Mineta, Katsuhiko, Archer, John A. C., Gojobori, Ta

Journal:

Year:

2017

Language:

english

File:

PDF, 3.03 MB

english, 2017

50

Female Infertility Caused by Mutations in the Oocyte-Specific Translational Repressor PATL2

Maddirevula, Sateesh, Coskun, Serdar, Alhassan, Saad, Elnour, Atif, Alsaif, Hessa S., Ibrahim, Niema, Abdulwahab, Firdous, Arold, Stefan T., Alkuraya, Fowzan S.

Journal:

The American Journal of Human Genetics

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017